Two-photon uncaging of γ-aminobutyric acid in intact brain tissue
نویسندگان
چکیده
منابع مشابه
Two-photon uncaging of gamma-aminobutyric acid in intact brain tissue.
We have synthesized a photosensitive (or caged) 4-carboxymethoxy-5,7-dinitroindolinyl (CDNI) derivative of gamma-aminobutyric acid (GABA). Two-photon excitation of CDNI-GABA produced rapid activation of GABAergic currents in neurons in brain slices with an axial resolution of approximately 2 mum and enabled high-resolution functional mapping of GABA-A receptors. Two-photon uncaging of GABA, the...
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ژورنال
عنوان ژورنال: Nature Chemical Biology
سال: 2010
ISSN: 1552-4450,1552-4469
DOI: 10.1038/nchembio.321